Persistence of ivermectin in plasma and faeces following administration of a sustained-release bolus to cattle.
Res Vet Sci
; 66(1): 57-61, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-10088713
ABSTRACT
Six calves (weight 210 to 230 kg) were dosed with an intra-ruminal slow-release bolus prepared to deliver ivermectin at a low daily dosage for 135 days. Ivermectin concentrations in jugular blood 160 days post-treatment were determined by high performance liquid chromatography (HPLC) using fluorescence detection. Ivermectin plasma concentrations increased gradually to achieve the steady-state concentration (20 ng ml(-1)) at approximately four days post-treatment, which was maintained for 120 days. The ivermectin peak plasma concentration (28.5 ng ml(-1)) was attained at 15 days post-administration of the bolus. The faecal ivermectin concentration rose to a maximal concentration of 4.1 microg g(-1) at four days post-treatment, dropping to a steady-state concentration of around 1.18 microg g(-1) which was maintained up to 120 days post-treatment. Ivermectin was detected in both plasma (0.05 ng ml(-1)) and faeces (2.67 ng g(-1)) up to 160 days. The high levels of ivermectin recovered in faeces indicate that a large proportion of the dose released by the bolus (80 to 90 per cent) is excreted in faeces.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ivermectina
Límite:
Animals
Idioma:
En
Revista:
Res Vet Sci
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia