Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.
Trends Neurosci
; 22(4): 180-4, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10203856
ABSTRACT
Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to muscle spindles. In fact, intrafusal MyHCs are developmental isoforms expressed by the prenatal precursors of both intrafusal and extrafusal fibers. In adult limbs, developmental MyHCs persist in intrafusal, but not extrafusal fibers principally due to the afferent neurons that arrest their maturational replacement by MyHCs associated with faster shortening velocities. The slow shortening velocities that are characteristic of developmental MyHCs might be adaptive for precise calibration of muscle spindles as sense organs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
/
Fibras Musculares Esqueléticas
/
Cadenas Pesadas de Miosina
/
Isoformas de Proteínas
/
Desarrollo de Músculos
/
Mamíferos
Límite:
Animals
Idioma:
En
Revista:
Trends Neurosci
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos