Indomethacin-induced G1/S phase arrest of the plant cell cycle.
FEBS Lett
; 458(3): 349-53, 1999 Sep 24.
Article
en En
| MEDLINE
| ID: mdl-10570938
ABSTRACT
In animal systems, indomethacin inhibits cAMP production via a prostaglandin-adenylyl cyclase pathway. To examine the possibility that a similar mechanism occurs in plants, the effect of indomethacin on the cell cycle of a tobacco bright yellow 2 (TBY-2) cell suspension was studied. Application of indomethacin during mitosis did not interfere with the M/G1 progression in synchronized BY-2 cells but it inhibited cAMP production at the beginning of the G1 phase and arrested the cell cycle progression at G1/S. These observations are discussed in relation to the putative involvement of cAMP biosynthesis in the cell cycle progression in TBY-2 cells.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulfanilamidas
/
Ciclo Celular
/
Indometacina
Idioma:
En
Revista:
FEBS Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Bélgica