Whole body hyperthermia induction of soluble tumor necrosis factor receptors: implications for rheumatoid diseases.
J Rheumatol
; 26(12): 2513-6, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10606355
ABSTRACT
OBJECTIVE:
To test the hypothesis that 41.8 degrees C x 60 min whole body hyperthermia (WBH) induces increased serum levels of soluble necrosis factor receptors (sTNF-R).METHODS:
We tested the serum of cancer patients for changes in sTNF-RI and RII levels, as a function of time, pre and post (1) WBH alone, (2) WBH and chemotherapy, i.e., melphalan (L-PAM), and (3) L-PAM alone.RESULTS:
For sTNF-RI there was a marked increase (over pre-treatment values, i.e., 86%) in serum levels after WBH alone (n = 3), which peaked 2.5 h post-WBH; L-PAM (iv) only resulted in a dip in sTNF-RI seen 40 min postadministration; the combination (WBH + L-PAM), resulted in both the dip at 40 min and the increase at 2.5 h post-treatment. For sTNF-RII both WBH alone (n = 3) and WBH + L-PAM (n = 2), there was an increase in receptor serum levels of 25% and 30%, respectively, which peaked 5.5 h post-treatment, and remained elevated at 24 h. L-PAM alone resulted in a dip in levels only at 40 min post-treatment. sTNF-RI and RII levels returned to baseline values within 7 days post-treatment.CONCLUSION:
41.8 degrees C WBH results in transient increases in TNF-RI and RII. These results may have therapeutic implications for the application of WBH to TNF mediated disease processes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Reumáticas
/
Receptores del Factor de Necrosis Tumoral
/
Hipertermia Inducida
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Rheumatol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos