Convergence between CD98 and integrin-mediated T-lymphocyte co-stimulation.
Immunology
; 99(1): 62-8, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10651942
ABSTRACT
CD98 is a widely expressed cell surface heterodimeric glycoprotein, which is rapidly up-regulated upon activation of T lymphocytes. Monoclonal antibody (mAb) 80A10 recognizes an epitope on CD98 and in combination with CD3 antibody causes proliferation of peripheral blood T lymphocytes. CD98 co-stimulatory activity, mediated by either mAb 80A10 or 4F2, a well-characterized CD98-specific mAb, is blocked in the presence of the soluble beta1 integrin antibody 18D3. Previously we have reported that co-stimulatory activity of antibodies to integrins alpha4beta1, alpha5beta1, alphaLbeta2 and alpha4beta7 is inhibited by 18D3, whereas co-stimulation mediated by non-integrins was unaffected. Thus the non-integrin CD98 is uniquely sensitive to the inhibitory effects of beta1 integrin-blocking antibodies, which may reflect convergent signalling mechanisms between integrins and CD98. This is consistent with recent reports suggesting that CD98 may regulate integrin-mediated adhesive events.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T
/
Transducción de Señal
/
Proteínas Portadoras
/
Antígenos CD
/
Integrinas
/
Complejo CD3
Límite:
Humans
Idioma:
En
Revista:
Immunology
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido