Allelic distribution of CCR5 and CCR2 genes in an Italian population sample.
AIDS Res Hum Retroviruses
; 16(2): 99-101, 2000 Jan 20.
Article
en En
| MEDLINE
| ID: mdl-10659048
ABSTRACT
Genetic polymorphisms of CCR5 and CCR2 human chemokine receptors have been associated with resistance during HIV-1 infection and disease progression. The protective effect of mutant alleles at these loci has important implications in AIDS pathogenesis. Chemokine receptors have a role in viral entry into target cells as well as in immune response modulation. In the present report, we studied the frequency of CCR5delta32 and CCR264I allelic variants among a representative sample of the Italian population. Observed allelic frequencies were 0.0454 and 0.0655, respectively. In both cases, genotype distribution was in equilibrium as predicted by the Hardy-Weinberg equation. Taken as a whole, about 21% of the population sample was found to be heterozygous for one or another of those two mutated alleles. Distribution of CCR5delta32 and CCR264I allelic variants within a population can be considered as a measure of genetic susceptibility to HIV infection and disease progression.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Citocinas
/
Receptores de Quimiocina
/
Receptores CCR5
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia