Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation.
J Leukoc Biol
; 67(2): 206-9, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10670581
ABSTRACT
Dendritic cell (DC) reconstitution experiments and phenotypic analysis of DC subpopulations have allowed the definition in the mouse of two main DC categories CD8+ lymphoid DCs and CD8- myeloid DCs. With regard to Langerhans cells (LCs), which represent immature DCs differentiating into mature DCs on migration to the lymph nodes after an antigenic stimulation, although classically considered as myeloid DCs, there is no experimental evidence of their origin. It has been recently shown that mouse LCs, negative for CD8 and LFA-1, undergo CD8/LFA-1 up-regulation on migration, suggesting that LCs belong to the CD8+ lymphoid DC lineage. To further reinforce this hypothesis, we have analyzed the modulation of CD8 expression by LCs on culture with molecules known to induce LC maturation. Our results show that LC acquired a CD8+ lymphoid phenotype on CD40 ligation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Dendríticas
/
Glicoproteínas de Membrana
/
Células de Langerhans
/
Antígenos CD8
/
Antígenos CD40
Límite:
Animals
Idioma:
En
Revista:
J Leukoc Biol
Año:
2000
Tipo del documento:
Article
País de afiliación:
España