The polyomavirus major capsid protein VP1 interacts with the nuclear matrix regulatory protein YY1.
FEBS Lett
; 467(2-3): 359-64, 2000 Feb 11.
Article
en En
| MEDLINE
| ID: mdl-10675569
ABSTRACT
Polyomavirus reaches the nucleus in a still encapsidated form, and the viral genome is readily found in association with the nuclear matrix. This association is thought to be essential for viral replication. In order to identify the protein(s) involved in the virus-nuclear matrix interaction, we focused on the possible roles exerted by the multifunctional cellular nuclear matrix protein Yin Yang 1 (YY1) and by the viral major capsid protein VP1. In the present work we report on the in vivo association between YY1 and VP1. Using the yeast two-hybrid system we demonstrate that the VP1 and YY1 proteins physically interact through the D-E region of VP1 and the activation domain of YY1.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas Nucleares
/
Cápside
/
Poliomavirus
/
Proteínas de la Cápside
/
Proteínas de Unión al ADN
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia