Depot-specific effects of early growth retardation on adipocyte insulin action.
Horm Metab Res
; 32(2): 71-5, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10741689
ABSTRACT
Male offspring of rats protein restricted during pregnancy and lactation are growth restricted and have changes in insulin action on epididymal adipocytes. Adipocytes from different anatomical depots are thought to have distinct metabolic functions. The aim of the present study was to determine whether the alterations in metabolism of adipocytes from early growth restricted rats is depot-specific or more generalised. Epididymal, intra-abdominal and subcutaneous adipocytes were studied from three-month-old male offspring of control and protein restricted dams. Basal glucose uptakes were higher in low protein adipocytes (p<0.01) compared to controls. However, insulin stimulation was less in the low protein group in all depots compared to controls (p<0.05). Isoproterenol-stimulated lipolysis was greater in low protein adipocytes (p<0.0001), but the magnitude was greater in epididymal (p<0.0001) and intra-abdominal (p<0.0001) adipocytes than in subcutaneous adipocytes. Epididymal and intra-abdominal adipocytes from low protein offspring were also resistant to the anti-lipolytic action of insulin. These results suggest that certain changes associated with early growth retardation are depot-specific, being enhanced in the more metabolically active intra-abdominal and epididymal tissues.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adipocitos
/
Retardo del Crecimiento Fetal
/
Hipoglucemiantes
/
Insulina
/
Proteínas Musculares
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Horm Metab Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido