Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration.
J Biol Chem
; 275(31): 23421-4, 2000 Aug 04.
Article
en En
| MEDLINE
| ID: mdl-10840027
ABSTRACT
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activator of G-protein signaling), is a human Ras-related G-protein that defines a distinct subgroup of the Ras superfamily. Expression of AGS1 in yeast and in mammalian cells results in specific activation of Galpha(i)/Galpha(o) heterotrimeric signaling pathways. In addition, the in vivo and in vitro properties of AGS1 are consistent with it functioning as a direct guanine nucleotide exchange factor for Galpha(i)/Galpha(o). AGS1 thus presents a unique mechanism for signal integration via heterotrimeric G-protein signaling pathways.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Proto-Oncogénicas
/
Proteínas ras
/
Proteínas de Unión al GTP
/
Subunidades alfa de la Proteína de Unión al GTP Gi-Go
/
Proteínas de Unión al GTP Heterotriméricas
/
Factores de Intercambio de Guanina Nucleótido
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Biol Chem
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos