Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.
Neurosci Lett
; 287(2): 117-20, 2000 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-10854726
ABSTRACT
Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freely-moving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-field apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed significantly more locomotor activity (1210+/-270 cm) than sham-operated rats (420+/-70 cm), but only in the first 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163+/-21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These findings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bulbo Olfatorio
/
Estrés Fisiológico
/
Ácido Glutámico
/
Cuerpo Estriado
/
Conducta Exploratoria
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
China