Homogeneous longitudinal profiles and synchronous fluctuations of mitochondrial transmembrane potential.
FEBS Lett
; 475(3): 218-24, 2000 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-10869560
ABSTRACT
This study reports for the first time (a) the longitudinal profile of the transmembrane potential (mDeltapsi) of single mitochondria using a Nernstian fluorescent probe and (b) the distribution of mDeltapsi fluctuations of mitochondria undergoing permanent depolarization. Our findings show that (1) mitochondria in different energetic conditions coexist in the same cell, (2) mDeltapsi is rather homogeneous along the entire length of single mitochondria, (3) mDeltapsi is not influenced by the surrounding cytoplasmic environment and (4) mDeltapsi fluctuations occur simultaneously in groups of mitochondria connected in a network. Taken together, these findings provide further evidence for a functional relationship between mitochondrial arrangement and energetic condition.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Potenciales de la Membrana
/
Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia