Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens.

Lee, C S; Ryu, E J; Oh, S H; Paek, K S; Kim, M Y; Youn, H

Lee, C S; Ryu, E J; Oh, S H; Paek, K S; Kim, M Y; Youn, H.

Afiliación

Lee CS; Life Science R & D, LG Chemical Ltd, Toaejon, South Korea. csleed@lgchem.co.kr

Bioorg Med Chem Lett ; 10(18): 2123-7, 2000 Sep 18.

Article en En | MEDLINE | ID: mdl-10999485

ABSTRACT

ABSTRACT

The variety of cephalosporins 1 and 2 which possessed C(3)-aminopyrimidinyl substituents were prepared and evaluated for their antibacterial activities. They exhibited excellent in vitro activities especially against respiratory tract pathogens such as penicillin resistant Streptococcus pneumonia. Moraxella catarrhalis and Haemophilus influenza.

Asunto(s)

Cefalosporinas/síntesis química; Cefalosporinas/farmacología; Sistema Respiratorio/microbiología; Antiinfecciosos/síntesis química; Antiinfecciosos/farmacología; Cefdinir; Pruebas de Sensibilidad Microbiana; Pirimidinas/química; Relación Estructura-Actividad

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Respiratorio / Cefalosporinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2000 Tipo del documento: Article País de afiliación: Corea del Sur

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