Bioactive saponins from Swartzia schomburgkii from the suriname rainforest.
J Nat Prod
; 63(11): 1461-4, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11087583
ABSTRACT
Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five active (2, 4-7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC-MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4-6) showed weak cytotoxicity against the M-109 cell line.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Saponinas
País/Región como asunto:
America do sul
/
Caribe ingles
/
Suriname
Idioma:
En
Revista:
J Nat Prod
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos