Epidemiology of pneumococcal infections in French children.
Acta Paediatr Suppl
; 89(435): 27-9, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11194793
ABSTRACT
UNLABELLED Since 1977, resistance to beta-lactams and other families of antibiotics among isolates of Streptococcus pneumoniae has increased alarmingly worldwide. France is particularly affected by this phenomenon; in 1997 the French National Reference Centre for Pneumococci reported that 44% of S. pneumoniae strains were penicillin non-susceptible (PNSS). Furthermore, resistance to macrolides (53%) and sulphonamides (37%) was comparable; in addition, >50% of PNSS had a high level of resistance to penicillin and were multiresistant. The highest frequency of resistance is observed in children, particularly those with acute otitis media (AOM). CONCLUSION:
The clinical consequences of increasing antibiotic resistance are evident for meningitis and AOM, prompting clinicians to consider alternative agents such as high-dose cefotaxime (300 mg/ kg/d) or ceftriaxone (100mg/kg/d) plus vancomycin (60 mg/kg/d) for meningitis, and high-dose amoxicillin (> 80 mg/kg/d) or ceftriaxone (50 mg/kg/d) for AOM.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Neumocócicas
/
Streptococcus pneumoniae
/
Vigilancia de la Población
Tipo de estudio:
Screening_studies
Límite:
Adult
/
Child
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Paediatr Suppl
Año:
2000
Tipo del documento:
Article
País de afiliación:
Francia