Monophosphoryl lipid A adjuvant reverses a principal histologic parameter of formalin-inactivated respiratory syncytial virus vaccine-induced disease.
Vaccine
; 19(15-16): 2048-54, 2001 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-11228376
ABSTRACT
The mechanisms by which administration of a formalin-inactivated respiratory syncytial virus vaccine resulted in enhanced disease among children after they later became naturally infected with the virus remains largely undefined. After immunization and live virus challenge, the cotton rat demonstrated the histopathologic marker of the enhanced disease, polymorphonuclear leukocyte infiltration of lung alveolar spaces. We now report that immunization with formalin-inactivated vaccine formulated with the adjuvant, 3-deacylated monophosphoryl lipid A, dramatically reduces or eliminates the polymorphonuclear leukocyte infiltration within the alveoli of cotton rats post-challenge. We suggest, that this or similar adjuvants may be beneficial components of candidate non-replicating respiratory syncytial virus vaccines, whose development has been hampered by safety concerns.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus Sincitiales Respiratorios
/
Vacunas Virales
/
Adyuvantes Inmunológicos
/
Lípido A
Límite:
Animals
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Vaccine
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos