Simple skinfold-thickness measurements complement conventional anthropometric assessments in predicting glucose tolerance.
Am J Clin Nutr
; 73(3): 567-73, 2001 Mar.
Article
en En
| MEDLINE
| ID: mdl-11237933
ABSTRACT
BACKGROUND:
Skinfold-thickness measurements are considered to have limited clinical utility.OBJECTIVE:
To assess whether skinfold-thickness measurements may be a useful adjunct to conventional anthropometric assessments in predicting glucose and insulin regulation, we studied responses to replicate 75-g oral-glucose-tolerance tests (OGTTs) and performed simple anthropometry in a cross section of subjects.DESIGN:
Thirty-five subjects completed the study 11 lean [mean (+/-SEM) age 33 +/- 3.2 y; body mass index (BMI; in kg/m(2)) 24.1 +/- 0.8; and percentage body fat (%BF) 11.5 +/- 1.5%], 12 normal-weight (age 33 +/- 2.9 y; BMI 23.9 +/- 0.7; and %BF 24.3.5 +/- 1.3%), and 12 obese (age 41 +/- 4.5 y; BMI 34.5 +/- 1.7; and %BF 34.2 +/- 1.5%) individuals. The lean and normal-weight groups were selected to have similar BMIs but different %BFs. We measured the participants' heights, weights, %BFs, waist circumferences, hip circumferences, and truncal and peripheral skinfold thicknesses. Subjects received nine 75-g OGTTs and blood samples were collected at 0, 15, 30, 45, 60, 90, and 120 min. Mean plasma glucose and insulin values were used to calculate the insulin sensitivity index.RESULTS:
The obese group had higher plasma glucose concentrations and areas under the curve (AUCs) than did the normal-weight or lean group and higher plasma insulin concentrations and AUCs than did the lean group (P < 0.05). Stepwise multiple regression, with adjustment for demographic and anthropometric measurements, identified the following predictors waist circumference, peripheral skinfold thickness, and BMI for fasting plasma glucose (partial R(2) = 0.20, 0.13, and 0.13, P < 0.05); waist circumference and truncal skinfold thickness for plasma glucose AUC (partial R(2) = 0.20 and 0.13, P < 0.05); age, waist-to-hip ratio, and peripheral skinfold thickness for fasting plasma insulin (partial R(2) = 0.26, 0.22, and 0.15, P < 0.05); truncal skinfold thickness for plasma insulin AUC (partial R(2) = 0.41, P < 0.001); and peripheral skinfold thickness for both 2-h plasma glucose (partial R(2) = 0.59, P < 0.001) and the insulin sensitivity index (partial R(2) = 0.49, P < 0.001).CONCLUSION:
Skinfold-thickness measurements may complement other established measurements for predicting abnormal glucose and insulin regulation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Grosor de los Pliegues Cutáneos
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Glucemia
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Tejido Adiposo
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Insulina
/
Obesidad
Tipo de estudio:
Diagnostic_studies
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Observational_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2001
Tipo del documento:
Article
País de afiliación:
Canadá