Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice.
Virus Res
; 75(1): 75-86, 2001 May.
Article
en En
| MEDLINE
| ID: mdl-11311430
ABSTRACT
In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like viruses from eastern and western Canadian deer mice can be divided into at least two broad-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed that SN-like virus genogroups appeared to be associated with distinct haplotypes of mice. Sera from deer mice infected with eastern and western viral genotypes neutralized the Sin Nombre virus strain, Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian SN-like strains these hantaviruses do not appear to define unique hantavirus serotypes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Peromyscus
/
Orthohantavirus
/
Proteínas de la Cápside
Límite:
Animals
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Virus Res
Asunto de la revista:
VIROLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Canadá