Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection.
Transplantation
; 71(8): 1058-60, 2001 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-11374402
ABSTRACT
INTRODUCTION:
The enterocyte-specific protein, intestinal fatty acid binding protein (I-FABP), is detectable in serum only after intestinal injury. Previous studies in animals suggest that I-FABP might be a useful marker of intestinal allograft rejection. MATERIALS ANDMETHODS:
I-FABP was repetitively measured in nine intestinal transplant recipients and correlated with findings of surveillance endoscopy.RESULTS:
Average interval between I-FABP determination and biopsy was 3.4 days (SD=4.2 days). Average number of rejection episodes per patient totalled 1.6+/-1.2. General linear modeling demonstrated no tendency for increases in serum FABP to precede histologic graft rejection (P=0.263). Restriction of the analysis to I-FABP determinations 1 day before or on the day of biopsy failed to affect these results. Minor increases in I-FABP were often associated with histologically normal grafts, whereas rejection often occurred when I-FABP was not detectable.DISCUSSION:
Serum I-FABP levels do not predict clinical intestinal allograft rejection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante Homólogo
/
Proteínas Portadoras
/
Proteínas Supresoras de Tumor
/
Rechazo de Injerto
/
Intestinos
/
Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Transplantation
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos