A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.
Science
; 293(5527): 98-101, 2001 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-11441182
ABSTRACT
The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The beta(2) adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(v)1.2. This complex also contained a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase, and the counterbalancing phosphatase PP2A. Our electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel. The assembly of this signaling complex provides a mechanism that ensures specific and rapid signaling by a G protein-coupled receptor.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Receptores Adrenérgicos beta 2
/
Canales de Calcio Tipo L
Idioma:
En
Revista:
Science
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos