Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla.
Peptides
; 22(8): 1331-8, 2001 Aug.
Article
en En
| MEDLINE
| ID: mdl-11457529
Serotonin 5-HT(3) antagonists have been suggested for treatment of several disorders involving altered gastrointestinal (GI) function. CCK also has well documented GI actions on both food intake and vago-vagal reflexes. To evaluate potential interactions, the effect of a 5-HT(3) antagonist, ondansetron, on exogenous CCK induced satiety and c-fos activation was determined. Ondansetron reduced both actions of CCK by approximately 50%. The reduction in c-fos was localized to a specific subregion of the dorsal medulla, suggesting that a distinct subpopulation of CCK receptive fibers are modulated by 5-HT(3) ligands. Treatments using 5-HT(3) antagonists also may affect endogenous CCK functions.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Colecistoquinina
/
Proteínas Proto-Oncogénicas c-fos
/
Ondansetrón
/
Conducta Alimentaria
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos