Cytokines, from atopy to asthma: the Th2 dogma revisited.
Cell Mol Biol (Noisy-le-grand)
; 47(4): 679-87, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11502075
ABSTRACT
Asthma is a spreading condition in Western countries, in most cases in relationship with atopy. Atopy is defined by an individual predisposition to develop allergic diseases in response to environmental allergens. The atopic immune system is characterized by a Th2 deviation determined by genetic and environmental factors. Among these factors, the role of allergen exposure, dietary behavior, air pollution and early exposure to microbes is discussed. In asthma, a Th2 cell activation is evident, but is accompanied by a Tc1 cell activation. These Tc1 cells probably down-regulate Th2 cells, but are also relevant to the bronchial hyperresponsiveness characterizing asthma. We propose that Tc1 activation in asthma could be the link between allergy and bronchial hyperresponsiveness.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Citocinas
/
Células Th2
/
Hipersensibilidad Inmediata
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Cell Mol Biol (Noisy-le-grand)
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia