Cytokines and troponin-I in cardiac dysfunction after coronary artery grafting with cardiopulmonary bypass.
Arq Bras Cardiol
; 77(2): 107-19, 2001 Aug.
Article
en En, Pt
| MEDLINE
| ID: mdl-11514822
ABSTRACT
OBJECTIVE:
The association between cytokines and troponin-I with cardiac function after cardiac surgery with cardiopulmonary bypass remains a topic of continued investigation.METHODS:
Serial measurements, within 24h following surgery, of tumor necrosis factor-alpha, its soluble receptors, and troponin-I were performed in patients with normal ejection fraction undergoing coronary artery bypass grafting. Ejection fraction was measured by radioisotopic ventriculography preoperatively, at 24h and at day 7 postoperatively.RESULTS:
Of 19 patients studied (59+/-8.5 years), 10 (group 1) showed no changes in ejection fraction, 53+/-8% to 55+/-7%, and 9 (group 2) had a decrease in ejection fraction, 60+/-11% to 47+/-11% (p=0.015) before and 24h after coronary artery bypass grafting, respectively. All immunological variables, except tumor necrosis factor-alpha soluble receptor I at 3h postoperation (5.5+/- 0.5 in group 1 versus 5.9+/-0.2 pg/ml in group 2; p=0.048), were similar between groups. Postoperative troponin-I had an inverse correlation with ejection fraction at 24h (r= -0.44).CONCLUSIONS:
Inflammatory activity, assessed based on tumor necrosis factor-alpha and its receptors, appears to play a minor role in cardiac dysfunction after cardiac surgery. Troponin I levels are inversely associated with early postoperative ejection fraction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Citocinas
/
Factor de Necrosis Tumoral alfa
/
Troponina I
/
Circulación Extracorporea
/
Revascularización Miocárdica
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
/
Pt
Revista:
Arq Bras Cardiol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Brasil