A high molecular weight RNA fraction in chromatin.
Biochim Biophys Acta
; 383(1): 40-55, 1975 Feb 24.
Article
en En
| MEDLINE
| ID: mdl-1168079
ABSTRACT
Utilizing a new chromatin isolation and fractionation technique we have obtained a high molecular weight RNA fraction from L-929 cell chromatin. The synthesis of this RNA is not greatly inhibited by concentrations of 0.04 mug/ml actinomycin D in the medium. Its synthesis appears to be strongly inhibited by 2 mug/ml of alpha-amanitin. The RNA appears to be quickly degraded (or removed from the chromatin) and does not contain a poly(A) sequence at its 3'-OH terminal end. Our working hypothesis is that this RNA is "nascent" heterogenous nuclear RNA partially transcribed from regions of the chromatin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN
/
Cromatina
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1975
Tipo del documento:
Article