Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
Immunity
; 15(6): 909-19, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11754813
ABSTRACT
NK1.1(+) T cells develop and function through interactions with cell surface CD1 complexes. In I-A(b) mice lacking the invariant chain (Ii) processing enzyme, cathepsin S, NK1.1(+) T cell selection and function are impaired. In vitro, thymic dendritic cells (DCs) from cathepsin S(-/-) mice exhibit defective presentation of the CD1-restricted antigen, alpha-galactosylceramide (alpha-GalCer). CD1 dysfunction is secondary to defective trafficking of CD1, which colocalizes with Ii fragments and accumulates within endocytic compartments of cathepsin S(-/-) DCs. I-A(k), cathepsin S(-/-) mice do not accumulate class II-associated Ii fragments and accordingly do not display CD1 abnormalities. Thus, function of CD1 is critically linked to processing of Ii, revealing MHC class II haplotype and cathepsin S activity as regulators of NK T cells.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Antígenos de Diferenciación de Linfocitos B
/
Antígenos de Histocompatibilidad Clase II
/
Catepsinas
/
Superantígenos
/
Supresión Clonal
/
Presentación de Antígeno
/
Antígenos CD1
/
Galactosilceramidas
Límite:
Animals
Idioma:
En
Revista:
Immunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos