Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus)(1).
FEBS Lett
; 510(3): 171-4, 2002 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-11801248
ABSTRACT
To elucidate the evolution of SEN virus (SEN-V), serial sequences of chronically SEN-V-infected patients were analyzed. In the hypervariable regions, non-synonymous substitutions significantly predominated. This could be attributed to positive selection in evading immune surveillance of the hosts and to establish a persistent infection. On the basis of the sequences in the two open reading frames of SEN-V DNA, the rate of synonymous substitutions was 7.32 x 10(-4) per site per year. Since this rate is close to RNA viruses and higher than other DNA viruses, the SEN-V might be replicated by machinery with poor or no proofreading function.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Selección Genética
/
Infecciones por Circoviridae
/
Circoviridae
/
Regiones Determinantes de Complementariedad
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos