Proliferative marker Ki-67 in gallbladder carcinomas: high expression level predicts early recurrence after surgical resection.
Cancer Lett
; 176(2): 191-8, 2002 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-11804747
ABSTRACT
To evaluate the prognostic value of proliferative maker Ki-67, its expression was determined immunohistochemically in 37 gallbladder carcinomas (GBCs). A high Ki-67 index was significantly correlated with tumor lymphatic invasion (P=0.007) and vascular invasion (P=0.04). High Ki-67 index group and low Ki-67 index group showed different clinical courses. Five patients who experienced recurrences in high Ki-67 index group developed their recurrent diseases within one year after surgery and died soon after recurrence, while the recurrences (five cases) in low Ki-67 index group were distributed all stages after surgery. In conclusion, high Ki-67 index predicts early recurrence after surgery for GBCs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma
/
Antígeno Ki-67
/
Neoplasias de la Vesícula Biliar
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Lett
Año:
2002
Tipo del documento:
Article