wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila.
Neuron
; 33(4): 545-58, 2002 Feb 14.
Article
en En
| MEDLINE
| ID: mdl-11856529
ABSTRACT
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evoked excitatory junctional potentials, decreased levels of the synaptic cell adhesion molecule Fasciclin II, and synaptic membrane detachment at active zones. Wit is expressed by a subset of neurons, including motoneurons. The NMJ phenotype is specifically rescued by transgenic expression of Wit only in motoneurons. Thus, Wit appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Central
/
Proteínas Serina-Treonina Quinasas
/
Regulación del Desarrollo de la Expresión Génica
/
Tipificación del Cuerpo
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Mutación
/
Unión Neuromuscular
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos