Reverse engineering of biological complexity.
Science
; 295(5560): 1664-9, 2002 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-11872830
ABSTRACT
Advanced technologies and biology have extremely different physical implementations, but they are far more alike in systems-level organization than is widely appreciated. Convergent evolution in both domains produces modular architectures that are composed of elaborate hierarchies of protocols and layers of feedback regulation, are driven by demand for robustness to uncertain environments, and use often imprecise components. This complexity may be largely hidden in idealized laboratory settings and in normal operation, becoming conspicuous only when contributing to rare cascading failures. These puzzling and paradoxical features are neither accidental nor artificial, but derive from a deep and necessary interplay between complexity and robustness, modularity, feedback, and fragility. This review describes insights from engineering theory and practice that can shed some light on biological complexity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Teoría de Sistemas
/
Retroalimentación Fisiológica
/
Ingeniería
/
Fenómenos Fisiológicos
/
Modelos Biológicos
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Science
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos