Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging.
Neuron
; 33(5): 827-40, 2002 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-11879658
ABSTRACT
Frontal contributions to cognitive decline in aging were explored using functional MRI. Frontal regions active in younger adults during self-initiated (intentional) memory encoding were under-recruited in older adults. Older adults showed less activity in anterior-ventral regions associated with controlled use of semantic information. Under-recruitment was reversed by requiring semantic elaboration suggesting it stemmed from difficulty in spontaneous recruitment of available frontal resources. In addition, older adults recruited multiple frontal regions in a nonselective manner for both verbal and nonverbal materials. Lack of selectivity was not reversed during semantically directed encoding even when under-recruitment was diminished. These findings suggest two separate forms of age-associated change in frontal cortex under-recruitment and nonselective recruitment. The former is reversible and potentially amenable to cognitive training; the latter may reflect a less malleable change associated with cognitive decline in advanced aging.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reclutamiento Neurofisiológico
/
Envejecimiento
/
Lóbulo Frontal
/
Memoria
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos