A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: characterization of the aberration by multicolor banding.
Int J Oncol
; 20(6): 1179-81, 2002 Jun.
Article
en En
| MEDLINE
| ID: mdl-12011996
ABSTRACT
We report on a patient with a clinically diagnosed Philadelphia negative chronic myelogenous leukemia (CML) with a so far unrecorded complex translocation event between the two homologue chromosomes 5. At the GTG-band level the karyotype was normal, apart from an enlarged chromosome 5 and an extremely shortened second chromosome 5. Both derivative chromosomes 5 consisted exclusively of #5 derived material as proven by 24-color FISH. To characterize the complex aberration in more detail the multicolor banding (MCB) technique using a chromosome 5 specific probe set was applied. Using this DNA-based high resolution banding procedure, the karyotype could be described as 46,XX,del(5)(pterright curved arrow q12q33right curved arrow qter),ins(5)(pterright curved arrow q15q12right curved arrow q21q21right curved arrow qter). In consequence, the aberration leads to a partial deletion of the long arm of chromosome 5 del(5)(q21q33), which would not have been identified using conventional banding techniques or 24-color FISH.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
Cromosomas Humanos Par 5
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Bandeo Cromosómico
/
Deleción Cromosómica
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Int J Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania