Anticipation of age at onset of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder.
Psychiatry Res
; 111(1): 1-9, 2002 Aug 05.
Article
en En
| MEDLINE
| ID: mdl-12140114
ABSTRACT
Anticipation of age at onset has been observed in several neuropsychiatric disorders. Recent studies have associated anticipation with the presence of unstable DNA and have suggested that trinucleotide repeats may be the main cause in some of these diseases. However, several selection biases may mimic the presence of such an effect. In this study we evaluated the presence of this effect in 40 families of probands with obsessive-compulsive disorder (OCD) compared with affected subjects in the parental generation. We controlled for ascertainment biases by taking into account the age at interview of probands. Using a different recruitment strategy, we controlled for anticipation in a sub-sample of offspring of 13 OCD patients, affected with OC spectrum disorders. While the younger generation showed a significantly earlier age at onset than the parental generation, no effect of age at interview was observed. Drawing on the results, we hypothesised that the presence of anticipation in OCD and OC spectrum disorders could be due to a specific genetic effect (unstable DNA), as it has been hypothesised for other disorders showing this effect.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos de Tic
/
Trastorno Obsesivo Compulsivo
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Psychiatry Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Italia