Plasma theophylline level and ventilatory function in chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate.
Eur J Clin Pharmacol
; 8(2): 119-23, 1975 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-1233208
ABSTRACT
Plasma levels of theophylline and broncholytic activity have been studied in 12 patients with chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate, administered as a press-coated tablet (BrondaxinR). The plasma levels determined immediately before and 80 minutes after each dose showed very good agreement with those calculated on the basis of data from a previous single dose study. The plasma concentration and improvement in ventilatory function were closely correlated throughout the 48 hours of the study. A tendency towards further reduction of bronchial obstruction was observed during the second day, despite essentially unchanged plasma levels of theophylline. The results provide a rational basis for determination of an optimal dose schedule for oral treatment with choline theophyllinate to reduce the symptoms of obstructive bronchial disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Respiración
/
Teofilina
/
Colina
/
Enfermedades Pulmonares Obstructivas
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
1975
Tipo del documento:
Article