Your browser doesn't support javascript.
loading
Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion.
Nguyen Khac, Florence; Waill, Marie Christine; Romana, Serge P; Radford-Weiss, Isabelle; Busson, Maryvonne; Collonge-Rame, Marie Agnès; Ribadeau-Dumas, Antoine; Piffaut, Marie-Claude; Daniel, Marie-Thérèse; Davi, Frédéric; Merle-Béral, Hélène; Berger, Roland; Arock, Michel.
Afiliación
  • Nguyen Khac F; Service d'Hématologie Biologique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. florence.nguyen@psl.ap-hop-paris.fr
Cancer Genet Cytogenet ; 138(1): 22-6, 2002 Oct 01.
Article en En | MEDLINE | ID: mdl-12419580
ABSTRACT
Two patients with Ph-positive chronic myelocytic leukemia in erythroblastic transformation and rearrangement of the short arm of chromosome 18 are reported. Fluorescence in situ hybridization studies showed that the 18p rearrangement resulted from translocation of the main part of chromosome 22 long arm to 18p, including BCR-ABL1 fusion. The 18p abnormality resulted, thus, in loss of 18p and duplication of BCR-ABL1 in both patients. The possible relation to the erythroblastic type of blastic phase is briefly discussed. In addition an apparently intact germline ABL1 gene was duplicated and inserted into chromosome 6 at band p21 in one of these patients.
Asunto(s)
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 18 / Leucemia Mielógena Crónica BCR-ABL Positiva / Transformación Celular Neoplásica / Proteínas de Fusión bcr-abl / Duplicación de Gen / Eritrocitos Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cancer Genet Cytogenet Año: 2002 Tipo del documento: Article País de afiliación: Francia
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 18 / Leucemia Mielógena Crónica BCR-ABL Positiva / Transformación Celular Neoplásica / Proteínas de Fusión bcr-abl / Duplicación de Gen / Eritrocitos Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cancer Genet Cytogenet Año: 2002 Tipo del documento: Article País de afiliación: Francia