Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion.
Cancer Genet Cytogenet
; 138(1): 22-6, 2002 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-12419580
ABSTRACT
Two patients with Ph-positive chronic myelocytic leukemia in erythroblastic transformation and rearrangement of the short arm of chromosome 18 are reported. Fluorescence in situ hybridization studies showed that the 18p rearrangement resulted from translocation of the main part of chromosome 22 long arm to 18p, including BCR-ABL1 fusion. The 18p abnormality resulted, thus, in loss of 18p and duplication of BCR-ABL1 in both patients. The possible relation to the erythroblastic type of blastic phase is briefly discussed. In addition an apparently intact germline ABL1 gene was duplicated and inserted into chromosome 6 at band p21 in one of these patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 18
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Leucemia Mielógena Crónica BCR-ABL Positiva
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Transformación Celular Neoplásica
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Proteínas de Fusión bcr-abl
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Duplicación de Gen
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Eritrocitos
Límite:
Aged
/
Aged80
/
Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia