Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study.
Acta Anaesthesiol Scand
; 46(10): 1206-11, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12421192
ABSTRACT
BACKGROUND:
Extensive blood loss in total knee replacement (TKR) surgery is well known and is associated with a high transfusion rate of allogenic blood. Tranexamic acid (TXA) has been shown to reduce blood loss by 50% in this patient group, but only in cases with a perioperative loss of 1400-1800 ml. This study was performed to see if TXA offers any advantages in knee replacement surgery with blood loss at 800 ml.METHODS:
Thirty consecutive patients scheduled for TKR in spinal anesthesia with the use of a tourniquet, were randomized to TXA or non-TXA. Tranexamic acid 10 mg kg-1 was given at conclusion of surgery and again 3 h later. Blood loss was registered.RESULTS:
Total blood loss was at all times significantly lower in the TXA group compared to the non-TXA group (409.7+/-174.9 ml vs. 761.7+/-313.1 ml; P<0.001). There were no differences in coagulation parameters. No patients in the TXA group had a blood transfusion vs. 13% in the non-TXA group (NS). No complications were registered in the two groups.CONCLUSION:
We conclude that TXA significantly reduces blood loss after total knee replacement surgery.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Tranexámico
/
Pérdida de Sangre Quirúrgica
/
Hemostasis Endoscópica
/
Artroplastia de Reemplazo de Rodilla
/
Cuidados Intraoperatorios
/
Antifibrinolíticos
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Anaesthesiol Scand
Año:
2002
Tipo del documento:
Article
País de afiliación:
Dinamarca