CCR4-bearing T cells participate in autoimmune diabetes.
J Clin Invest
; 110(11): 1675-86, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12464673
ABSTRACT
Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells. CCR4 was found exclusively on memory CD4(+) T cells during the progression of disease in NOD mice. Cells expressing the CCR4 ligand TARC (thymus- and activation-regulated chemokine) were detected within infiltrated islets from prediabetic mice. Interestingly, neutralization of macrophage-derived chemokine (MDC) with Ab caused a significant reduction of CCR4-positive T cells within the pancreatic infiltrates and inhibited the development of insulitis and diabetes. Furthermore, enhanced recruitment of CCR4-bearing cells in NOD mice resulting from transgenic expression of MDC resulted in acceleration of clinical disease. Cumulatively, the results demonstrate that CCR4-bearing T cells participate in the development of such tissue-driven autoimmune reactions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Receptores de Quimiocina
/
Diabetes Mellitus Tipo 1
Límite:
Animals
Idioma:
En
Revista:
J Clin Invest
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos