Anoikis: roadblock to cell transplantation?
Cell Transplant
; 11(7): 621-30, 2002.
Article
en En
| MEDLINE
| ID: mdl-12518889
ABSTRACT
Cell therapy, in particular liver cell transplantation, holds great therapeutic potential and is partially hindered by the high rate of apoptosis during cell isolation, cryopreservation, and engraftment. Apoptosis occurring due to cell detachment from the extracellular matrix is a phenomenon termed "anoikis." The purpose of this review is to describe signaling mechanisms pertinent to anoikis in both immortalized cell lines, but particularly in primary normal epithelial cells. The mechanisms described include integrin signaling and survival molecules, caspase activation, and the role of mitochondrial proteins in anoikis. Strategies to prevent anoikis during isolation and cryopreservation of hepatocytes are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adhesión Celular
/
Separación Celular
/
Trasplante de Células
/
Hepatocitos
/
Anoicis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2002
Tipo del documento:
Article
País de afiliación:
Israel