[Solubility behavior of four diastereomeric salts and two amino acids in near-critical CO2].
Yao Xue Xue Bao
; 37(5): 355-8, 2002 May.
Article
en Zh
| MEDLINE
| ID: mdl-12579840
ABSTRACT
AIM:
To establish a suitable condition for extraction of phenylalanine (Phe), 5-hydroxytryptophan (5-OH-Trp) and four diastereomeric salts, (1R,2S)-ephedrine- (2S,3S)-tartaric acid, (1R,2S)-ephedrine-(2R,3R)-tartaric acid, (1S,2S)-pseudoephedrine-(2S,3S)-tartaric acid, (1S,2S)-pseudoephedrine- (2R,3R)-tartaric acid in supercritical fluid extraction and to assess the solubilities of Phe, 5-OH-Trp and the four diastereomeric salts in CO2.METHODS:
Single-pass method and HPCE.RESULTS:
The solubilities of Phe, 5-OH-Trp and the four diastereomeric salts in CO2 were determined over temperature and pressure ranges of 25-50 degrees C and 6.32-34.03 MPa respectively. The experimental results showed that the solubilities of Phe, 5-OH-Trp and the four diastereomeric salts do not increase with density of CO2. There existed a maximum in the critical region of CO2.CONCLUSION:
The dramatically high solubilities in the pressure of 6.32-7.78 MPa show a critical behavior, which can be explained by critical characteristic through thermodynamics analysis. The results suggest that the separation of Phe, 5-OH-Trp and the four diastereomeric salts is more efficient in critical region of CO2.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenilalanina
/
Tartratos
/
5-Hidroxitriptófano
/
Efedrina
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2002
Tipo del documento:
Article
País de afiliación:
China