Reinfection, rather than persistent infection, in patients with chronic granulomatous disease.
J Infect Dis
; 187(5): 845-53, 2003 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-12599059
Chronic granulomatous disease (CGD) is characterized by severe recurrent infections with Staphylococcus aureus, certain gram-negative rods, Nocardia species, and fungi. When infections with the same species recur, they may represent relapses or new infections. We collected organisms from infections that occurred between 1992 and 2000 in patients with CGD and determined the biochemical phenotypes, in vitro antibiotic susceptibility patterns, and pulsed-field gel electrophoresis (PFGE) patterns of the organisms causing the initial and recurrent infections. Recurrence of infection with Burkholderia cepacia or Serratia marcescens was caused by a new strain in 9 of 10 cases (P=.001). Recurrent S. aureus infections were caused by new strains in 7 of 8 cases (P=.006). In patients with CGD, recurrence of infection with the same bacterial species after appropriate antibiotic therapy usually represents new infection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumonía Bacteriana
/
Enfermedad Granulomatosa Crónica
Límite:
Adolescent
/
Adult
/
Child
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos