CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice.
Vaccine
; 21(19-20): 2492-9, 2003 Jun 02.
Article
en En
| MEDLINE
| ID: mdl-12744883
ABSTRACT
Unmethylated CpG oligonucleotides (CpG-ODN) increase adult and neonatal primary antibody responses to T-dependent antigens, at yet unidentified stages of antigen-specific B cell differentiation. In adult mice, a single dose of CpG-ODN adjuvanted tetanus toxoid (TT) vaccine markedly enhanced and prolonged splenic TT-specific antibody-secreting-cell (ASC) responses and significantly increased the size of the bone marrow (BM) ASC pool. Surprisingly, this was not associated with changes of germinal center (GC) numbers, size, apoptosis or function. In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligodesoxirribonucleótidos
/
Tétanos
/
Toxoide Tetánico
/
Fosfatos de Dinucleósidos
/
Anticuerpos Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2003
Tipo del documento:
Article
País de afiliación:
Suiza