Increase of preprotachykinin mRNA in the uninjured mandibular neurons after rat infraorbital nerve transection.
Neurosci Lett
; 345(1): 57-60, 2003 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-12809988
ABSTRACT
An increasing number of studies are suggesting that the adjacent uninjured primary afferents contribute to the mechanisms of neuropathic pain following peripheral nerve injury. In this study, we report that transection of the infraorbital nerve, a major branch of the maxillary nerve, causes exaggerated face grooming to normally innocuous mechanical stimuli in the skin territory of the uninjured mandibular nerve, and increases the expression of preprotachykinin mRNA in the primary afferent neurons in the mandibular zone in the trigeminal ganglia. Considering the various functions of substance P in the sensory transmission process, the increase in preprotachykinin mRNA in the uninjured primary afferent neurons may be one of the mechanisms of pain-related behavior in this neuropathic pain model.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
ARN Mensajero
/
Taquicininas
/
Nervio Mandibular
/
Nervio Maxilar
/
Neuronas Aferentes
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón