Anti-inflammatory activity of neutrophil elastase inhibitors.
Curr Opin Investig Drugs
; 4(5): 556-65, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12833649
ABSTRACT
Neutrophil elastase is a protease that is involved in the tissue destruction and inflammation that characterize numerous diseases, including hereditary emphysema, chronic obstructive pulmonary disease, cystic fibrosis, adult respiratory distress syndrome, ischemic-reperfusion injury and rheumatoid arthritis. Thus, elastase has been the object of extensive research to develop potent inhibitors that target its destructive and pro-inflammatory action. This review focuses on the anti-inflammatory activity of inhibitors that are currently, or were until recently in development, including purified or recombinantly produced endogenous inhibitors, genetically modified recombinant protein inhibitors and synthetic small-molecule inhibitors.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antiinflamatorios no Esteroideos
/
Elastasa de Leucocito
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Investig Drugs
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2003
Tipo del documento:
Article
País de afiliación:
Canadá