Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry.
Arzneimittelforschung
; 53(5): 307-13, 2003.
Article
en En
| MEDLINE
| ID: mdl-12854357
ABSTRACT
A specific, sensitive and precise method for the simultaneous determination of spirapril (CAS 94841-17-5) and spiraprilat (CAS 83602-05-5) in human plasma is described. The method involves the use of enalapril as internal standard, solid-phase extraction, derivatization and capillary gas chromatography with mass sensitive detection. The working range is from 2.5 to 500 micrograms/l for spirapril and spiraprilat, respectively. Data demonstrating the precision and accuracy of the analytical method are given. Moreover, data concerning freeze-thaw stability, long-term stability of frozen samples, short-term stability of thawed samples, and stability of the extracts in the autosampler are given.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de la Enzima Convertidora de Angiotensina
/
Enalapril
Límite:
Humans
Idioma:
En
Revista:
Arzneimittelforschung
Año:
2003
Tipo del documento:
Article