Beta-endorphin and neurotensin in brainstem and cerebrospinal fluid in the sudden infant death syndrome.
Neurochem Int
; 20(1): 97-102, 1992 Jan.
Article
en En
| MEDLINE
| ID: mdl-1304324
ABSTRACT
Beta-endorphin (BE) and neurotensin (NT) are two neuropeptides which induce apneas. In infants who died of Sudden Infant Death Syndrome (SIDS) we measured, in brainstem and CSF, BE and NT by IRMA and RIA respectively. BE and NT levels are compared to same aged infant and adult controls. CSF BE level was significantly higher in SIDS than in the two control groups (86 +/- 14 vs 33 +/- 13 and 16 +/- 5 pmol/l). In 6 SIDS victims NT and BE were assayed in 5 brainstem sections, each of them divided in median, intermediate and lateral parts. We found high levels of BE in every fragment (3-11 pmol/mg protein) while NT elevated values were restricted to the mesencephalic regions (1.4-12 pmol/mg), the medial pons (6 pmol/mg) and the intermediate parts of the medulla (including the olive 1.3-1.6 pmol/mg). These results support the hypothesis that NT and/or BE could induce or participate to the fetal issue of SIDS.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Muerte Súbita del Lactante
/
Tronco Encefálico
/
Neurotensina
/
Betaendorfina
Límite:
Adult
/
Humans
/
Infant
Idioma:
En
Revista:
Neurochem Int
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia