p56lyn catalyzes a reversible autophosphorylation reaction and a nucleoside diphosphate kinase reaction.
FEBS Lett
; 309(3): 275-8, 1992 Sep 14.
Article
en En
| MEDLINE
| ID: mdl-1325373
ABSTRACT
The reversible autophosphorylation of the pp60c-src family tyrosine kinase, p56lyn has been characterized by a simple procedure that involves the examination of the enzyme catalyzed radioisotope exchange between ATP and ADP. The equilibrium constant of the reaction was determined to be 3.31 and corresponded to a standard free energy of hydrolysis of the phosphotyrosine bond in p56lyn of -8.08 kcal/mol. GDP was capable of substituting for ADP as phosphate acceptor so that p56lyn displayed a nucleoside diphosphate kinase activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfotransferasas
/
Proteínas Tirosina Quinasas
/
Nucleósido-Difosfato Quinasa
/
Familia-src Quinasas
/
Complejos Multienzimáticos
Idioma:
En
Revista:
FEBS Lett
Año:
1992
Tipo del documento:
Article
País de afiliación:
Canadá