Monocyte mediated cytotoxic activity against melanoma.
Melanoma Res
; 1(5-6): 303-9, 1992.
Article
en En
| MEDLINE
| ID: mdl-1422187
ABSTRACT
The appearance of macrophages in human tumours, the so called tumour-infiltrating or tumour-associated macrophages (TIM or TAM) has suggested a role for these cells in host defence mechanisms against cancer. In this review we discuss monocyte-mediated cytotoxic activity against melanoma, as reported by a number of different authors. Although most studies described in this review have used melanoma cell lines as targets for monocyte/macrophage cytotoxicity, it would be incomplete if cytotoxicity against other target cells such as K562 or WEHI-164 is not discussed. At least two distinct mechanisms of killing by monocytes/macrophages can be distinguished; direct recognition and cytotoxicity by the effector cells and antibody-mediated lysis of the tumour cells (antibody-dependent cellular cytotoxicity, ADCC). Both types of cytotoxicity will be discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Monocitos
/
Macrófagos
/
Melanoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Melanoma Res
Asunto de la revista:
NEOPLASIAS
Año:
1992
Tipo del documento:
Article