Extracellular ATP stimulates elastase secretion from human neutrophils and increases lung resistance and secretion from normal rat airways after intratracheal instillation.
Can J Physiol Pharmacol
; 70(7): 1065-8, 1992 Jul.
Article
en En
| MEDLINE
| ID: mdl-1451029
ABSTRACT
The effect of ATP on intracellular Ca2+ levels and elastase secretion in isolated normal human peripheral blood neutrophils was investigated as was its in vivo effect on lung resistance and mucous secretion. ATP (10(-5) M) increased [Ca2+]i from 61 +/- 3 to 165 +/- 15 nM in nonactivated neutrophils; elastase secretion was increased by 40% from nonactivated neutrophils but was unaffected in fMLP (10(-5) M) activated cells. Instillation of ATP (10(-5) and 10(-3) M) into the airways of brown Norway rats increased both lung resistance and secretion. These findings suggest that aerosolization of ATP into the cystic fibrosis-affected bronchial tree might be hazardous in terms of enhancement of parenchymal damage, which would result from neutrophil elastase release, and in terms of impaired respiratory lung function.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Elastasa Pancreática
/
Adenosina Trifosfato
/
Resistencia de las Vías Respiratorias
/
Neutrófilos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Can J Physiol Pharmacol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Canadá