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The rise and fall of NMDA antagonists for ischemic stroke.
Hoyte, L; Barber, P A; Buchan, A M; Hill, M D.
Afiliación
  • Hoyte L; Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Curr Mol Med ; 4(2): 131-6, 2004 Mar.
Article en En | MEDLINE | ID: mdl-15032709
It has long been accepted that high concentrations of glutamate can destroy neurons, and this is the basis of the theory of excitotoxicity during brain injury such as stroke. Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists such as Selfotel, Aptiganel, Gavestinel and others failed to show neuroprotective efficacy in human clinical trials or produced intolerable central nervous system adverse effects. The failure of these agents has been attributed to poor studies in animal models and to poorly designed clinical trials. We also speculate that NMDA receptor antagonism may have hindered endogenous mechanisms for neuronal survival and neuroregeneration. It remains to be proven in human stroke whether NMDA receptor antagonism can be neuroprotective.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / N-Metilaspartato / Receptores de N-Metil-D-Aspartato / Antagonistas de Aminoácidos Excitadores / Accidente Cerebrovascular / Isquemia Límite: Animals / Humans Idioma: En Revista: Curr Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2004 Tipo del documento: Article País de afiliación: Canadá
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / N-Metilaspartato / Receptores de N-Metil-D-Aspartato / Antagonistas de Aminoácidos Excitadores / Accidente Cerebrovascular / Isquemia Límite: Animals / Humans Idioma: En Revista: Curr Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2004 Tipo del documento: Article País de afiliación: Canadá