N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.

Carson, John R; Coats, Steven J; Codd, Ellen E; Dax, Scott L; Lee, Jung; Martinez, Rebecca P; McKown, Linda A; Anne Neilson, Lou; Pitis, Philip M; Wu, Wu-Nan; Zhang, Sui-Po

Carson, John R; Coats, Steven J; Codd, Ellen E; Dax, Scott L; Lee, Jung; Martinez, Rebecca P; McKown, Linda A; Anne Neilson, Lou; Pitis, Philip M; Wu, Wu-Nan; Zhang, Sui-Po.

Afiliación

Carson JR; Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, PO 776, Spring House, PA 19477-0776, USA. jcarson@prdus.jnj.edu

Bioorg Med Chem Lett ; 14(9): 2113-6, 2004 May 03.

Article en En | MEDLINE | ID: mdl-15080990

ABSTRACT

ABSTRACT

The tertiary amide delta opioid agonist 2 is a potent antinociceptive agent. Compound 2 was metabolized in vitro and in vivo to secondary amide 3, a potent and selective micro opioid agonist. The SAR of a series of N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides was examined.

Asunto(s)

Analgésicos/farmacología; Benzamidas/farmacología; Receptores Opioides delta/agonistas; Receptores Opioides mu/agonistas; Analgésicos/química; Benzamidas/química; Relación Estructura-Actividad

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Receptores Opioides delta / Receptores Opioides mu / Analgésicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos

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