Effect of a dietary n-6 polyunsaturated fatty acid supplement on distinct immune functions of goats.
J Vet Med A Physiol Pathol Clin Med
; 51(1): 1-9, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-15086503
ABSTRACT
The aim of this study was to investigate whether dietary n-6 polyunsaturated fatty acids (PUFA) alter immune functions as lymphocyte blastogenesis, expression of lymphocyte and monocyte markers, and cell adhesion molecules of the integrin family in goats. Dutch White castrated male goats received a diet either rich in olive oil (control group, n = 4) or rich in corn oil (test group, n = 4) over a period of 3 weeks. The animals in the test group had significantly higher linoleic acid (LA, 182n-6) levels in plasma on days 7, 14 and 21 of the diet than control animals. This was also true for washed erythrocyte membranes at day 21. A significant reduction in the percentage of alpha-4 integrin (CD49d) expressing lymphocytes was observed in goats fed LA rich corn oil at day 21. However, no changes were observed in either lymphocyte proliferative responses to ConA and PHA or the expression of other lymphocyte/monocyte markers. In conclusion, feeding corn oil rich in LA caused significant increases in the proportion of LA in the fatty acid composition of plasma and erythrocyte membranes and was accompanied by a significant decrease of the adhesion molecule alpha-4 integrin (CD49d) on lymphocytes but not on monocytes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Grasas Insaturadas en la Dieta
/
Cabras
/
Linfocitos
/
Membrana Eritrocítica
Límite:
Animals
Idioma:
En
Revista:
J Vet Med A Physiol Pathol Clin Med
Año:
2004
Tipo del documento:
Article
País de afiliación:
Países Bajos